John A Gerlt: search on Z-Library

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1

Roles of Small Laccases from Streptomyces in Lignin Degradation

Majumdar, Sudipta, Lukk, Tiit, Solbiati, Jose O., Bauer, Stefan, Nair, Satish K., Cronan, John E., Gerlt, John A.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.00 MB

english, 2014

2

DIVERGENT EVOLUTION OF ENZYMATIC FUNCTION: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies

Gerlt, John A., Babbitt, Patricia C.

Journal:

Annual Review of Biochemistry

Year:

2001

Language:

english

File:

PDF, 783 KB

english, 2001

3

Comprehensive Natural Products Chemistry || Stabilization of Reactive Intermediates and Transition States in Enzyme Active Sites by Hydrogen Bonding

Year:

1999

Language:

english

File:

PDF, 556 KB

english, 1999

4

Divergent Function in the Crotonase Superfamily: An Anhydride Intermediate in the Reaction Catalyzed by 3-Hydroxyisobutyryl-CoA Hydrolase

Wong, Brian J., Gerlt, John A.

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

5

Thermal denaturation of staphylococcal nuclease

Calderon, Reyna O., Stolowich, Neal J., Gerlt, John A., Sturtevant, Julian M.

Journal:

Year:

1985

Language:

english

File:

PDF, 635 KB

english, 1985

6

Oxygen chiral phosphodiesters. 5. Stereochemical course of the hydrolysis of thymidine 3'-[(4-nitrophenyl)[17O,18O]phosphate] in water (oxygen-16) catalyzed by the exonuclease from bovine spleen

Mehdi, Shujaath, Gerlt, John A.

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 455 KB

english, 1981

7

Relationships between enzymatic catalysis and active site structure revealed by applications of site-directed mutagenesis

Journal:

Chemical Reviews

Year:

1987

Language:

english

File:

PDF, 6.00 MB

english, 1987

8

Theoretical calculations of hydrolysis energies of "high-energy" molecules. 3. Theoretical calculations on the geometric destabilization of 3',5'- and 2',3'-cyclic nucleotides

Marsh, Frederick J., Weiner, Paul, Douglas, John E., Kollman, Peter A., Kenyon, George L., Gerlt, John A.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 771 KB

english, 1980

9

Oxygen chiral phosphodiesters. 4. Stereochemical course of the hydrolysis of 2'-deoxyadenosine cyclic 3',5'-[17O, 18O]monophosphate in water(oxygen-16) catalyzed by bovine heart cyclic nucleotide phosphodiesterase

Coderre, Jeffrey A., Mehdi, Shujaath, Gerlt, John A.

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 594 KB

english, 1981

10

Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5'-Monophosphate Decarboxylase for Catalysis.

Reyes, Archie C., Plache, David C., Koudelka, Astrid P., Amyes, Tina L., Gerlt, John A., Richard, John P.

Journal:

Journal of the American Chemical Society

Year:

2018

Language:

english

File:

PDF, 2.32 MB

english, 2018

11

A bifunctional salvage pathway for two distinct S‐adenosylmethionine byproducts that is widespread in bacteria, including pathogenic Escherichia coli

North, Justin A., Wildenthal, John A., Erb, Tobias J., Evans, Bradley S., Byerly, Kathryn M., Gerlt, John A., Tabita, F. Robert

Journal:

Molecular Microbiology

Year:

2020

Language:

english

File:

PDF, 14.48 MB

english, 2020

12

Discovery of novel pathways for carbohydrate metabolism

Stack, Tyler M.M., Gerlt, John A.

Journal:

Current Opinion in Chemical Biology

Year:

2021

File:

PDF, 173 KB

2021

13

Chemical and Enzymatic Synthesis of Fluorinated-Dehydroalanine-Containing Peptides

Hao Zhou, Dawn M. Z. Schmidt, John A. Gerlt, Wilfred A. van der Donk

Journal:

Year:

2003

Language:

english

File:

PDF, 221 KB

english, 2003

14

ChemInform Abstract: The Crotonase Superfamily: Divergently Related Enzymes that Catalyze Different Reactions Involving Acyl Coenzyme A Thioesters

Hazel M. Holden, Matthew M. Benning, Toomas Haller, John A. Gerlt

Journal:

Year:

2001

File:

PDF, 25 KB

2001

15

Introduction

George L. Kenyon, John A. Gerlt

Journal:

Bioorganic Chemistry

Year:

2002

Language:

english

File:

PDF, 13 KB

english, 2002

16

A method for the observation of selected proton NMR resonances of proteins

Joyce A Wilde, Philip H Bolton, Neal J Stolowich, John A Gerlt

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 271 KB

english, 1969

17

How to Find “Missing” Genes

Journal:

Chemistry & Biology

Year:

2003

Language:

english

File:

PDF, 73 KB

english, 2003

18

Evolution of enzyme superfamilies

Margaret E Glasner, John A Gerlt, Patricia C Babbitt

Journal:

Current Opinion in Chemical Biology

Year:

2006

Language:

english

File:

PDF, 306 KB

english, 2006

19

Enzyme (re)design: lessons from natural evolution and computation

John A Gerlt, Patricia C Babbitt

Journal:

Current Opinion in Chemical Biology

Year:

2009

Language:

english

File:

PDF, 385 KB

english, 2009

20

Syntheses and configurational assignments of the diastereomers of the 4-nitrophenyl esters of thymidine 3′-(N-phenyl phosphoramidate) and thymidine 5′-(N-phenyl phosphoramidate)

John A. Gerlt, Shujaath Mehdi, Jeffrey A. Coderre, William O. Rogers

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 259 KB

english, 1980

21

Understanding enzymic catalysis: the importance of short, strong hydrogen bonds

John A. Gerlt, Maurice M. Kreevoy, W.W. Cleland, Perry A. Frey

Journal:

Chemistry & Biology

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

22

Mechanisms: Mechanisms of catalysis — macroscopic and microscopic progress

Michael A Marletta, John A Gerlt

Journal:

Current Opinion in Chemical Biology

Year:

2000

Language:

english

File:

PDF, 44 KB

english, 2000

23

Evolution of function in (β/α)8-barrel enzymes

John A Gerlt, Frank M Raushel

Journal:

Current Opinion in Chemical Biology

Year:

2003

Language:

english

File:

PDF, 350 KB

english, 2003

24

Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis

John A Gerlt, Patricia C Babbitt

Journal:

Current Opinion in Chemical Biology

Year:

1998

Language:

english

File:

PDF, 779 KB

english, 1998

25

Research highlights at the chemistry/biology interface: Editorial overview

John A Gerlt, Michael A Marletta

Journal:

Current Opinion in Chemical Biology

Year:

1998

Language:

english

File:

PDF, 289 KB

english, 1998

26

Oxygen chiral phosphodiesters—8 : Stereochemical course of the base-catalyzed hydrolysis of cyclic 2'-deoxyadenosine 3',5'-[17O, 18O]monophosphate

Shujaath Mehdi, Jeffrey A. Coderre, John A. Gerlt

Journal:

Year:

1983

Language:

english

File:

PDF, 900 KB

english, 1983

27

Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous

Neidhart, David J., Kenyon, George L., Gerlt, John A., Petsko, Gregory A.

Journal:

Year:

1990

File:

PDF, 354 KB

1990

28

Obituary: Frank H. Westheimer (1912–2007)

Journal:

Year:

2007

Language:

english

File:

PDF, 130 KB

english, 2007

29

10.1038/73249

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 228 KB

english, 2000

30

10.1038/83048

Gerlt, John A., Babbitt, Patricia C.

Journal:

Natural Structural Biology

Year:

2001

Language:

english

File:

PDF, 695 KB

english, 2001

31

“Fishing” for the functional proteome

Journal:

Nature Biotechnology

Year:

2002

Language:

english

File:

PDF, 67 KB

english, 2002

32

Acetoacetate decarboxylase: hydrophobics, not electrostatics

Journal:

Nature Chemical Biology

Year:

2009

Language:

english

File:

PDF, 212 KB

english, 2009

33

Orotidine 5′-Monophosphate Decarboxylase: Transition State Stabilization from Remote Protein–Phosphodianion Interactions

Amyes, Tina L., Ming, Shonoi A., Goldman, Lawrence M., Wood, B. McKay, Desai, Bijoy J., Gerlt, John A., Richard, John P.

Journal:

Year:

2012

Language:

english

File:

PDF, 355 KB

english, 2012

34

A Protein Structure (or Function ?) Initiative

Journal:

Year:

2007

Language:

english

File:

PDF, 91 KB

english, 2007

35

Discovery of a Dipeptide Epimerase Enzymatic Function Guided by Homology Modeling and Virtual Screening

Chakrapani Kalyanaraman, Heidi J. Imker, Alexander A. Fedorov, Elena V. Fedorov, Margaret E. Glasner, Patricia C. Babbitt, Steven C. Almo, John A. Gerlt, Matthew P. Jacobson

Journal:

Year:

2008

Language:

english

File:

PDF, 846 KB

english, 2008

36

Enzyme-catalyzed enolization reactions: a theoretical study on the energetics of concerted and stepwise pathways

Andrew L. Sargent, Mark E. Rollog, Jan E. Almlöf, Paul G. Gassman, John A. Gerlt

Journal:

Journal of Molecular Structure: THEOCHEM

Year:

1996

Language:

english

File:

PDF, 985 KB

english, 1996

37

Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity

John A. Gerlt, Patricia C. Babbitt, Ivan Rayment

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 935 KB

english, 2005

38

Evolution of Structure and Function in the o-Succinylbenzoate Synthase/N-Acylamino Acid Racemase Family of the Enolase Superfamily

Margaret E. Glasner, Nima Fayazmanesh, Ranyee A. Chiang, Ayano Sakai, Matthew P. Jacobson, John A. Gerlt, Patricia C. Babbitt

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.86 MB

english, 2006

39

Understanding enzyme-catalyzed proton abstraction from carbon acids: details of stepwise mechanisms for .beta.-elimination reactions

Gerlt, John A., Gassman, Paul G.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 1.02 MB

english, 1992

40

Protein engineering to study enzyme catalytic mechanisms

Journal:

Current Opinion in Structural Biology

Year:

1994

Language:

english

File:

PDF, 5.15 MB

english, 1994

41

OMP Decarboxylase: Phosphodianion Binding Energy Is Used To Stabilize a Vinyl Carbanion Intermediate

Goryanova, Bogdana, Amyes, Tina L., Gerlt, John A., Richard, John P.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 935 KB

english, 2011

42

An explanation for rapid enzyme-catalyzed proton abstraction from carbon acids: importance of late transition states in concerted mechanisms

Gerlt, John A., Gassman, Paul G.

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 2.26 MB

english, 1993

43

Evolutionary Potential of (β/α) 8 -Barrels: Functional Promiscuity Produced by Single Substitutions in the Enolase Superfamily †

Schmidt, Dawn M. Z., Mundorff, Emily C., Dojka, Michael, Bermudez, Ericka, Ness, Jon E., Govindarajan, Sridhar, Babbitt, Patricia C., Minshull, Jeremy, Gerlt, John A.

Journal:

Year:

2003

Language:

english

File:

PDF, 282 KB

english, 2003

44

A gold standard set of mechanistically diverse enzyme superfamilies

Shoshana D Brown, John A Gerlt, Jennifer L Seffernick, Patricia C Babbitt

Journal:

Year:

2006

Language:

english

File:

PDF, 440 KB

english, 2006

45

Can sequence determine function?

John A Gerlt, Patricia C Babbitt

Journal:

Year:

2000

Language:

english

File:

PDF, 483 KB

english, 2000

46

Proton Transfer from C-6 of Uridine 5′-Monophosphate Catalyzed by Orotidine 5′-Monophosphate Decarboxylase: Formation and Stability of a Vinyl Carbanion Intermediate and the Effect of a 5-Fluoro Substituent

Tsang, Wing-Yin, Wood, B. McKay, Wong, Freeman M., Wu, Weiming, Gerlt, John A., Amyes, Tina L., Richard, John P.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 667 KB

english, 2012

47

Role of a Guanidinium Cation–Phosphodianion Pair in Stabilizing the Vinyl Carbanion Intermediate of Orotidine 5′-Phosphate Decarboxylase-Catalyzed Reactions

Goryanova, Bogdana, Goldman, Lawrence M., Amyes, Tina L., Gerlt, John A., Richard, John P.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.16 MB

english, 2013

48

Stereochemical studies of the .beta.-elimination reactions at aldehydic abasic sites in DNA: endonuclease III from Escherichia coli, sodium hydroxide, and Lys-Trp-Lys

Mazumder, Abhijit, Gerlt, John A., Absalon, Michael J., Stubbe, JoAnne, Cunningham, Richard P., Withka, Jane, Bolton, Philip H.

Journal:

Year:

1991

Language:

english

File:

PDF, 2.10 MB

english, 1991

49

A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis

Erb, Tobias J, Evans, Bradley S, Cho, Kyuil, Warlick, Benjamin P, Sriram, Jaya, Wood, B McKay, Imker, Heidi J, Sweedler, Jonathan V, Tabita, F Robert, Gerlt, John A

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

50

On the origin of enzymatic species

Petsko, Gregory A., Kenyon, George L., Gerlt, John A., Ringe, Dagmar, Kozarich, John W.

Journal:

Trends in Biochemical Sciences

Year:

1993

Language:

english

File:

PDF, 573 KB

english, 1993